The permeability and efflux of Vinca alkaloids in a Caco-2 cell model

Vinca alkaloids are used extensively in the treatment of various diseases and despite their usefulness, drug resistance, attributed to a number mechanisms associated with multidrug-resistance phenotype including overexpression P-glycoprotein (P-gp), remains serious clinical problem. To identify possible role P-gp on intestinal permeability anti-arrhythmic crude (Vingerbine) from herbaceae, Caco-2 cells were this study. The four Vingerbine constituent analyzed by high performance liquid chromatography (HPLC). Transport parameters, coefficients percent transports calculated. displayed identical tendency but dissimilar degree modulation absorptive transport direction. Vincarine Herbadine demonstrated higher-level transcellular efflux; co-presence verapamil, increased, while secretory decreased. No asymmetric permeation was observed for Herbamine Vincamajine. study suggests involvement multidrug resistance-associated proteins (MRPs) efflux Herbadine. further studies will be focused upon screening appropriate nanomedicine-based strategies combat MDR thus improve absorption alkaloids.&nbsp